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Article

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects.

Basic & clinical pharmacology & toxicology - 1 Mar 2018

Neuvonen Mikko, Tarkiainen E Katriina, Tornio Aleksi, Hirvensalo Päivi, Tapaninen Tuija, Paile-Hyvärinen Maria, Itkonen Matti K, Holmberg Mikko T, Kärjä Vesa, Männistö Ville T, Neuvonen Pertti J, Pihlajamäki Jussi, Backman Janne T, Niemi Mikko

Abstract excerpt

Several single nucleotide variations (SNVs) affect carboxylesterase 1 (CES1) activity, but the effects of genetic variants on CES1 gene expression have not been systematically investigated. Therefore, our aim was to investigate effects of genetic variants on CES1 gene expression in two independent whole blood sample cohorts of 192 (discovery) and 88 (replication) healthy volunteers and in a liver sample cohort of...

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Identifiers

PMID: 28990360
DOI: 10.1111/bcpt.12916

Genes

CES1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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