Article
Carboxylesterase 1A2 encoding gene with increased transcription and potential rapid drug metabolism in Asian populations.
Drug metabolism and personalized therapy - 26 Sept 2017
Rasmussen Henrik Berg, Madsen Majbritt Busk, Lyauk Yassine Kamal, Hansen Peter Riis, Hughes Timothy
Abstract excerpt
The carboxylesterase 1 gene (CES1) encodes a hydrolase implicated in the metabolism of commonly used drugs. CES1A2, a hybrid of CES1 and a CES1-like pseudogene, has a promoter that is weak in most individuals. However, some individuals harbor a promoter haplotype of this gene with two overlapping Sp1 sites that confer significantly increased transcription potentially leading to rapid drug metabolism. This CES1A2...
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