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Article

Pharmacogenetic study of CES1 gene and enalapril efficacy.

Journal of applied genetics - 1 Sept 2024

Hussain Misbah, Basheer Sehrish, Khalil Adila, Haider Qurat Ul Ain, Saeed Hafsa, Faizan Muhammad

Abstract excerpt

Enalapril is an orally administered angiotensin-converting enzyme inhibitor which is widely prescribed to treat hypertension, chronic kidney disease, and heart failure. It is an ester prodrug that needs to be activated by carboxylesterase 1 (CES1). CES1 is a hepatic hydrolase that in vivo biotransforms enalapril to its active form enalaprilat in order to produce its desired pharmacological impact. Several single...

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Share to Angiotensin-Converting Enzyme Inhibitors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38261266
DOI: 10.1007/s13353-024-00831-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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