Article
GBA-Associated Parkinson's Disease: Progression in a Deep Brain Stimulation Cohort.
Journal of Parkinson's disease - 1 Jan 2017
Lythe Vanessa, Athauda Dilan, Foley Jennifer, Mencacci Niccolò E, Jahanshahi Marjan, Cipolotti Lisa, Hyam Jonathan, Zrinzo Ludvic, Hariz Marwan, Hardy John, Limousin Patricia, Foltynie Tom
Abstract excerpt
BACKGROUND: Recent evidence suggests that glucosidase beta acid (GBA) mutations predispose Parkinson's disease (PD) patients to a greater burden of cognitive impairment and non-motor symptoms. This emerging knowledge has not yet been considered in patients who have undergone deep brain stimulation (DBS); a surgery that is generally contraindicated in those with cognitive deficits. OBJECTIVE: To explore the...
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