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Article

Effect of deep brain stimulation on early-onset Parkinson's disease with mutations in a Han Chinese Mainland population.

BMC neurology - 5 Jan 2026

Chen Si, Yang Ning, Liu Jinde, Xu Shujun, Xu Shuo, Wang Jiwei, Li Chao, Liu Yi-Ming

Abstract excerpt

BACKGROUND: The influence of genetic factors on the efficacy of deep brain stimulation (DBS) remains unclear. This study aimed to analyze the effects of DBS in Han Chinese patients with early-onset Parkinson’s disease (EOPD) across various genetic backgrounds and to explore the differences in DBS responsiveness among patients EOPD with and distinct genetic profiles. METHODS: This retrospective study examined 48...

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Identifiers

PMID: 41486122
DOI: 10.1186/s12883-025-04593-8
PMCID: PMC12870255

Genes

PLA2G6
PINK1
PRKN

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