Article
Short-and long-term responsiveness of deep brain stimulation on motor and cognitive outcomes in GBA vs. Non-GBA parkinson's disease: a systematic review and meta-analysis of observational studies.
Neurosurgical review - 20 May 2026
Gonzales Romero Patrick Fabrizio, Bermejo Rosado Pierina, Paredes Torres Fabiana, Váscones-Román Fritz Fidel, Limbania Daniela, Pichardo-Rojas Diego, Quispe-Vicuña Carlos, Nuñez-Castellanos Carlos, Yazdanian Forough, Warren Aaron El, Pacheco-Barrios Niels, Rolston John D
Abstract excerpt
Deep brain stimulation (DBS) is an established therapy for motor complications in Parkinson's disease (PD). Patients carrying glucocerebrosidase (GBA) mutations exhibit distinct disease trajectories, raising questions regarding potential differences in clinical outcomes following DBS compared with non-carriers. To evaluate short- and long-term motor, medication, and cognitive outcomes following DBS in patients...
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