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Article

Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease.

Neurology - 16 Feb 2021

Maple-Grødem Jodi, Dalen Ingvild, Tysnes Ole-Bjørn, Macleod Angus D, Forsgren Lars, Counsell Carl E, Alves Guido

Abstract excerpt

OBJECTIVE: To establish the significance of glucocerebrosidase gene (GBA) carrier status on motor impairment in a large cohort of patients with incident Parkinson disease (PD). METHODS: Three European population-based studies followed 528 patients with PD from diagnosis. A total of 440 with genomic DNA from baseline were assessed for GBA variants. We evaluated motor and functional impairment annually using the...

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Identifiers

PMID: 33443131
DOI: 10.1212/WNL.0000000000011411
PMCID: PMC8055329

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