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Cognitive phenotyping of GBA1-Parkinson's disease: A study on deep brain stimulation outcomes.

Parkinsonism & related disorders - 1 Nov 2024

Fernández-Vidal Joan Miquel, Aracil-Bolaños Ignacio, García-Sánchez Carmen, Campolongo Antonia, Curell Mireia, Rodríguez-Rodriguez Rodrigo, Aibar-Duran Juan Ángel, Kulisevsky Jaime, Pascual-Sedano Berta

Abstract excerpt

BACKGROUND: Heterozygous variants in the glucocerebrosidase (GBA1) gene are the most common genetic risk factor for Parkinson's Disease (PD). GBA1-PD patients exhibit earlier disease onset, severe motor impairment, and heightened cognitive decline. Deep Brain Stimulation (DBS) offers motor improvement for PD patients, but its cognitive effects, particularly in GBA1-PD, are debated. METHODS: This study involved 96...

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PMID: 39357432
DOI: 10.1016/j.parkreldis.2024.107127

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