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Article

Faster disease progression in Parkinson's disease with glucocerebrosidase genotype: But not apparent immediate from diagnosis.

Journal of Parkinson's disease - 1 Nov 2025

Frequin Henrieke L, Ferwerda Bart, Verschuur Constant Vm, Suwijn Sven R, Dijk Joke M, de Bie Rob Ma

Abstract excerpt

BackgroundThis study presents post-hoc analyses of the LEAP study focusing on disease progression in patients with early Parkinson's disease (PD) who either have a glucocerebrosidase gene (GBA1) mutation (GBA1mut) or do not have a mutation (GBA1wt) over a period of up to five years.ObjectiveTo investigate the difference in disease progression between GBA1mut and GBA1wt over 80 weeks and five years.MethodsThe...

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Identifiers

PMID: 40899843
DOI: 10.1177/1877718X251361507
PMCID: PMC13347520

Genes

GBA1

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