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Article

GBA-associated PD: chances and obstacles for targeted treatment strategies.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Sept 2022

Höglinger Günter, Schulte Claudia, Jost Wolfgang H, Storch Alexander, Woitalla Dirk, Krüger Rejko, Falkenburger Björn, Brockmann Kathrin

Abstract excerpt

Given the clear role of GBA in the pathogenesis of Parkinson's disease (PD) and its impact on phenotypical characteristics, this review provides an overview of the current knowledge of GBA-associated PD with a special focus on clinical trajectories and the underlying pathological mechanisms. Importantly, differences and characteristics based on mutation severity are recognized, and current as well as potential...

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Identifiers

PMID: 35639160
DOI: 10.1007/s00702-022-02511-7
PMCID: PMC9463270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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