Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Features of GBA-associated Parkinson's disease at presentation in the UK Tracking Parkinson's study.

Journal of neurology, neurosurgery, and psychiatry - 1 Jul 2018

Malek Naveed, Weil Rimona S, Bresner Catherine, Lawton Michael A, Grosset Katherine A, Tan Manuela, Bajaj Nin, Barker Roger A, Burn David J, Foltynie Thomas, Hardy John, Wood Nicholas W, Ben-Shlomo Yoav, Williams Nigel W, Grosset Donald G, Morris Huw R

Abstract excerpt

OBJECTIVES: To examine the influence of the glucocerebrosidase (GBA) mutation carrier state on age at onset of Parkinson's disease (PD), the motor phenotype and cognitive function at baseline assessment in a large cohort of UK patients. We also analysed the prevalence of mood and behavioural problems that may confound the assessment of cognitive function. METHODS: We prospectively recruited patients with PD in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Cognitive Dysfunction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Dementia

Share to Glucosylceramidase

Share to Heterozygote

Share to Parkinson Disease

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 29378790
DOI: 10.1136/jnnp-2017-317348
PMCID: PMC6031283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Features of GBA-associated Parkinson's disease at presentation in the UK Tracking Parkinson's study.PMID 29378790Read ↗

GBA-associated PD: chances and obstacles for targeted treatment strategies.Semantic proximity Read ↗

GBA, Gaucher Disease, and Parkinson’s Disease: From Genetic to Clinic to New Therapeutic ApproachesSemantic proximity Read ↗

A benign course of Parkinson's disease associated with different mutations in the glucocerebrosidase gene - A case series.Semantic proximity Read ↗

GBA-Related Parkinson's Disease: Dissection of Genotype-Phenotype Correlates in a Large Italian Cohort.Semantic proximity Read ↗

Who is at Risk of Parkinson Disease? Refining the Preclinical Phase of GBA1 and LRRK2 Variant Carriers: a Clinical, Biochemical, and Imaging Approach.Semantic proximity Read ↗

Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease.Semantic proximity Read ↗

Exploring the Genotype–Phenotype Correlation in GBA-Parkinson Disease: Clinical Aspects, Biomarkers, and Potential ModifiersSemantic proximity Read ↗

Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.Semantic proximity Read ↗

Impact of GBA1 variants on long-term clinical progression and mortality in incident Parkinson's disease.Semantic proximity Read ↗

The link between the GBA gene and parkinsonism.Semantic proximity Read ↗

A Global Perspective of GBA1-Related Parkinson's Disease: A Narrative Review.Semantic proximity Read ↗

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.