Parkinson Disease and Subthalamic Nucleus Deep Brain Stimulation: Cognitive Effects in GBA Mutation Carriers.

doi:10.1002/ana.26302

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Article

Parkinson Disease and Subthalamic Nucleus Deep Brain Stimulation: Cognitive Effects in GBA Mutation Carriers.

Annals of neurology - 1 Mar 2022

Pal Gian, Mangone Graziella, Hill Emily J, Ouyang Bichun, Liu Yuanqing, Lythe Vanessa, Ehrlich Debra, Saunders-Pullman Rachel, Shanker Vicki, Bressman Susan, Alcalay Roy N, Garcia Priscilla, Marder Karen S, Aasly Jan, Mouradian M Maral, Link Samantha, Rosenbaum Marc, Anderson Sharlet, Bernard Bryan, Wilson Robert, Stebbins Glenn, Nichols William C, Welter Marie-Laure, Sani Sepehr, Afshari Mitra, Verhagen Leo, de Bie Rob M A, Foltynie Tom, Hall Deborah, Corvol Jean-Christophe, Goetz Christopher G

Abstract excerpt

OBJECTIVE: This study was undertaken to compare the rate of change in cognition between glucocerebrosidase (GBA) mutation carriers and noncarriers with and without subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. METHODS: Clinical and genetic data from 12 datasets were examined. Global cognition was assessed using the Mattis Dementia Rating Scale (MDRS). Subjects were examined for...

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PMID: 34984729
DOI: 10.1002/ana.26302
PMCID: PMC8857042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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