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Article

HIT'nDRIVE: patient-specific multidriver gene prioritization for precision oncology.

Genome research - 1 Sept 2017

Shrestha Raunak, Hodzic Ermin, Sauerwald Thomas, Dao Phuong, Wang Kendric, Yeung Jake, Anderson Shawn, Vandin Fabio, Haffari Gholamreza, Collins Colin C, Sahinalp S Cenk

Abstract excerpt

Prioritizing molecular alterations that act as drivers of cancer remains a crucial bottleneck in therapeutic development. Here we introduce HIT'nDRIVE, a computational method that integrates genomic and transcriptomic data to identify a set of patient-specific, sequence-altered genes, with sufficient collective influence over dysregulated transcripts. HIT'nDRIVE aims to solve the "random walk facility location"...

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PMID: 28768687
DOI: 10.1101/gr.221218.117
PMCID: PMC5580716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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