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Article

Multi-scale cancer driver gene prediction by flexible data selection and network topology guidance.

Journal of biomedical informatics - 1 Dec 2025

Liu Jian, Ren Yingzan, Xiao Guodong, Li Ponian, Sun Chuanqi, Chen Jiaxin, Ma Fubin, Gao Rui, Mi Jia, Cong Haiyan, Wang Mingyi, Zhang Yusen

Abstract excerpt

OBJECTIVE: Efficient and comprehensive prioritization of cancer driver genes across individual patients, cancer cohorts, and pan-cancer is crucial for advancing cancer diagnosis and treatment. The existing methods are effective, but they seem to have reached a plateau in accuracy enhancement and lack broad-scale joint analysis, flexibility in adapting to cancer and interpretability. METHODS: Here, we introduce...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41276241
DOI: 10.1016/j.jbi.2025.104961

Genes

ANK3
CENPF
COL7A1

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