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Article

PITCH: A Pathway-Induced Prioritization of Personalized Cancer Driver Genes Based on Higher-Order Interactions.

IEEE journal of biomedical and health informatics - 1 Jun 2025

Wang Yuhe, Jin Suoqin, Zou Xiufen

Abstract excerpt

Cancer is driven by specific mutations known as cancer driver genes, whose identification is crucial for advancing cancer therapy. Although many computational methods have been proposed with this purpose, most provide a single driver gene list ignoring the high heterogeneity of drivers across patients in cohort. Besides, they often fail to capture the higher-order interactions among genes at the patient level....

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PMID: 40031738
DOI: 10.1109/JBHI.2025.3538536

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