Article
DriverRWH: discovering cancer driver genes by random walk on a gene mutation hypergraph.
BMC bioinformatics - 13 Jul 2022
Wang Chenye, Shi Junhan, Cai Jiansheng, Zhang Yusen, Zheng Xiaoqi, Zhang Naiqian
Abstract excerpt
BACKGROUND: Recent advances in next-generation sequencing technologies have helped investigators generate massive amounts of cancer genomic data. A critical challenge in cancer genomics is identification of a few cancer driver genes whose mutations cause tumor growth. However, the majority of existing computational approaches underuse the co-occurrence mutation information of the individuals, which are deemed to...
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