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Advancing cancer driver gene identification through an integrative network and pathway approach.

Journal of biomedical informatics - 1 Oct 2024

Song Junrong, Song Zhiming, Gong Yuanli, Ge Lichang, Lou Wenlu

Abstract excerpt

OBJECTIVE: Cancer is a complex genetic disease characterized by the accumulation of various mutations, with driver genes playing a crucial role in cancer initiation and progression. Distinguishing driver genes from passenger mutations is essential for understanding cancer biology and discovering therapeutic targets. However, the majority of existing methods ignore the mutational heterogeneity and commonalities...

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PMID: 39306314
DOI: 10.1016/j.jbi.2024.104729

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