Article
Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization.
Molecular cell - 20 Jul 2017
Diebold-Durand Marie-Laure, Lee Hansol, Ruiz Avila Laura B, Noh Haemin, Shin Ho-Chul, Im Haeri, Bock Florian P, Bürmann Frank, Durand Alexandre, Basfeld Alrun, Ham Sihyun, Basquin Jérôme, Oh Byung-Ha, Gruber Stephan
Abstract excerpt
Multi-subunit SMC complexes control chromosome superstructure and promote chromosome disjunction, conceivably by actively translocating along DNA double helices. SMC subunits comprise an ABC ATPase "head" and a "hinge" dimerization domain connected by a 49 nm coiled-coil "arm." The heads undergo ATP-dependent engagement and disengagement to drive SMC action on the chromosome. Here, we elucidate the architecture...
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