Article
Overall Shapes of the SMC-ScpAB Complex Are Determined by Balance between Constraint and Relaxation of Its Structural Parts.
Structure (London, England : 1993) - 4 Apr 2017
Kamada Katsuhiko, Su'etsugu Masayuki, Takada Hiraku, Miyata Makoto, Hirano Tatsuya
Abstract excerpt
The SMC-ScpAB complex plays a crucial role in chromosome organization and segregation in many bacteria. It is composed of a V-shaped SMC dimer and an ScpAB subcomplex that bridges the two Structural Maintenance of Chromosomes (SMC) head domains. Despite its functional significance, the mechanistic details of SMC-ScpAB remain obscure. Here we provide evidence that ATP-dependent head-head engagement induces a lever...
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