Article
An asymmetric SMC-kleisin bridge in prokaryotic condensin.
Nature structural & molecular biology - 1 Mar 2013
Bürmann Frank, Shin Ho-Chul, Basquin Jérôme, Soh Young-Min, Giménez-Oya Victor, Kim Yeon-Gil, Oh Byung-Ha, Gruber Stephan
Abstract excerpt
Eukaryotic structural maintenance of chromosomes (SMC)-kleisin complexes form large, ring-shaped assemblies that promote accurate chromosome segregation. Their asymmetric structural core comprises SMC heterodimers that associate with both ends of a kleisin subunit. However, prokaryotic condensin Smc-ScpAB is composed of symmetric Smc homodimers associated with the kleisin ScpA in a postulated symmetrical manner....
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