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Turning the Mre11/Rad50 DNA repair complex on its head: lessons from SMC protein hinges, dynamic coiled-coil movements and DNA loop-extrusion?

Biochemical Society transactions - 18 Dec 2020

Zabolotnaya Ekaterina, Mela Ioanna, Henderson Robert M, Robinson Nicholas P

Abstract excerpt

The bacterial SbcC/SbcD DNA repair proteins were identified over a quarter of a century ago. Following the subsequent identification of the homologous Mre11/Rad50 complex in the eukaryotes and archaea, it has become clear that this conserved chromosomal processing machinery is central to DNA repair pathways and the maintenance of genomic stability in all forms of life. A number of experimental studies have...

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PMID: 33300987
DOI: 10.1042/BST20170168
PMCID: PMC7752040

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Turning the Mre11/Rad50 DNA repair complex on its head: lessons from SMC protein hinges, dynamic coiled-coil movements and DNA loop-extrusion?PMID 33300987Read ↗

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