Article
Multistep assembly of DNA condensation clusters by SMC.
Nature communications - 4 Jan 2016
Kim HyeongJun, Loparo Joseph J
Abstract excerpt
SMC (structural maintenance of chromosomes) family members play essential roles in chromosome condensation, sister chromatid cohesion and DNA repair. It remains unclear how SMCs structure chromosomes and how their mechanochemical cycle regulates their interactions with DNA. Here we used single-molecule fluorescence microscopy to visualize how Bacillus subtilis SMC (BsSMC) interacts with flow-stretched DNAs. We...
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