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Article

Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.

Developmental biology - 1 Sept 2017

Hoelzl Maria A, Heby-Henricson Karin, Gerling Marco, Dias José M, Kuiper Raoul V, Trünkle Cornelius, Bergström Åsa, Ericson Johan, Toftgård Rune, Teglund Stephan

Abstract excerpt

Suppressor of Fused (SUFU) is an essential negative regulator of the Hedgehog (HH) pathway and involved in GLI transcription factor regulation. Due to early embryonic lethality of Sufu-/- mice, investigations of SUFU's role later in development are limited to conditional, tissue-specific knockout models. In this study we developed a mouse model (SufuEx456(fl)/Ex456(fl)) with hypomorphic features where embryos...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28688895
DOI: 10.1016/j.ydbio.2017.06.037
PMCID: PMC5569906

Genes

SUFU
GLI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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