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Article

Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus.

Molecular and cellular biology - 1 Aug 2005

Merchant Mark, Evangelista Marie, Luoh Shiuh-Ming, Frantz Gretchen D, Chalasani Sreedevi, Carano Richard A D, van Hoy Marjie, Ramirez Julio, Ogasawara Annie K, McFarland Leanne M, Filvaroff Ellen H, French Dorothy M, de Sauvage Frederic J

Abstract excerpt

The Drosophila Fused (Fu) kinase is an integral component of the Hedgehog (Hh) pathway that helps promote Hh-dependent gene transcription. Vertebrate homologues of Fu function in the Hh pathway in vitro, suggesting that Fu is evolutionarily conserved. We have generated fused (stk36) knockout mice to address the in vivo function of the mouse Fu (mFu) homologue. fused knockouts develop normally, being born in...

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Identifiers

PMID: 16055717
DOI: 10.1128/MCB.25.16.7054-7068.2005
PMCID: PMC1190232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus.PMID 16055717Read ↗

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