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Article

Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused.

Development (Cambridge, England) - 1 Oct 2005

Cooper Ayanna F, Yu Kuan Ping, Brueckner Martina, Brailey Lisa L, Johnson Linda, McGrath James M, Bale Allen E

Abstract excerpt

The hedgehog (Hh) pathway is conserved from Drosophila to humans and plays a key role in embryonic development. In addition, activation of the pathway in somatic cells contributes to cancer development in several tissues. Suppressor of fused is a negative regulator of Hh signaling. Targeted disruption of the murine suppressor of fused gene (Sufu) led to a phenotype that included neural tube defects and lethality...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16155214
DOI: 10.1242/dev.02021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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