Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development.

Abstract excerpt

Hedgehog (Hh) signaling plays a major role in multiple aspects of embryonic development. To understand how a single Hh signal is capable of generating distinct readouts in Hh-responsive cells requires elucidation of the signal transduction cascade at the molecular level. Key components that mediate Hh signal transduction downstream of the receptor include Fused (Fu), Suppressor of fused (Sufu), and Costal-2...

Topics

• Alleles
• Alternative Splicing
• Animals
• Axin Protein
• Blotting, Northern
• Gene Expression Regulation, Developmental
• Hedgehog Proteins
• In Situ Hybridization
• Mice
• Mice, Transgenic
• Models, Genetic
• Mutation
• Phenotype