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Article

Genomic organization and embryonic expression of Suppressor of Fused, a candidate gene for the split-hand/split-foot malformation type 3.

FEBS letters - 7 Sept 2001

Grimm T, Teglund S, Tackels D, Sangiorgi E, Gurrieri F, Schwartz C, Toftgård R

Abstract excerpt

The genes for human and mouse Suppressor of Fused (SU(FU)/Su(Fu)) in the Hedgehog signaling pathway were characterized and found to contain 12 exons. Human SU(FU) localized on chromosome 10q24-25 between the markers D10S192 and AFM183XB12. We detected three additional SU(FU) isoforms, two of which have lost their ability to interact with the transcription factor GLI1. Expression analysis using whole mount in situ...

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Share to Chromosomes, Human, Pair 10
Share to Foot Deformities, Congenital

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Hand Deformities, Congenital

Share to In Situ Hybridization

Share to Mice, Inbred Strains

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Source

Identifiers

PMID: 11557033
DOI: 10.1016/s0014-5793(01)02682-5

Genes

GLI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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