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Article

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.

Developmental cell - 1 Feb 2006

Svärd Jessica, Heby-Henricson Karin, Henricson Karin Heby, Persson-Lek Madelen, Rozell Björn, Lauth Matthias, Bergström Asa, Ericson Johan, Toftgård Rune, Teglund Stephan

Abstract excerpt

The Hedgehog (Hh) pathway plays important roles during embryogenesis and carcinogenesis. Here, we show that ablation of the mouse Suppressor of fused (Sufu), an intracellular pathway component, leads to embryonic lethality at approximately E9.5 with cephalic and neural tube defects. Fibroblasts derived from Sufu(-/-) embryos showed high Gli-mediated Hh pathway activity that could not be modulated at the level of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16459298
DOI: 10.1016/j.devcel.2005.12.013

Genes

GLI1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.PMID 16459298Read ↗

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