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Article

Characterization of the human Suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

1 Dec 1999

Abstract excerpt

Drosophila Suppressor of fused (Su(fu)) encodes a novel 468-amino-acid cytoplasmic protein which, by genetic analysis, functions as a negative regulator of the Hedgehog segment polarity pathway. Here we describe the primary structure, tissue distribution, biochemical and functional analyses of a human Su(fu) (hSu(fu)). Two alternatively spliced isoforms of hSu(fu) were identified, predicting proteins of 433 and...

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Identifiers

PMID: 10564661
DOI: 10.1242/jcs.112.23.4437

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Characterization of the human Suppressor of fused, a negative regulator of the zinc-finger transcription factor GliPMID 10564661Read ↗

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Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulationSemantic proximity Read ↗

Genomic organization and embryonic expression of Suppressor of Fused, a candidate gene for the split-hand/split-foot malformation type 3.Semantic proximity Read ↗

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Novel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant.Semantic proximity Read ↗

SCL/TAL1 Interrupting Locus Derepresses GLI1 from the Negative Control of Suppressor-of-Fused in Pancreatic Cancer CellSemantic proximity Read ↗

The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and DiseasesSemantic proximity Read ↗

Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.Semantic proximity Read ↗

Mutations in SUFU predispose to medulloblastoma.Semantic proximity Read ↗

GLIS1–3 transcription factors: critical roles in the regulation of multiple physiological processes and diseasesSemantic proximity Read ↗

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