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Article

Hypoxia Inducible Factor-2 Alpha and Prolinhydroxylase 2 Polymorphisms in Patients with Acute Respiratory Distress Syndrome (ARDS).

International journal of molecular sciences - 14 Jun 2017

Dötsch Annika, Eisele Lewin, Rabeling Miriam, Rump Katharina, Walstein Kai, Bick Alexandra, Cox Linda, Engler Andrea, Bachmann Hagen S, Jöckel Karl-Heinz, Adamzik Michael, Peters Jürgen, Schäfer Simon T

Abstract excerpt

Hypoxia-inducible-factor-2α (HIF-2α) and HIF-2 degrading prolyl-hydroxylases (PHD) are key regulators of adaptive hypoxic responses i.e., in acute respiratory distress syndrome (ARDS). Specifically, functionally active genetic variants of HIF-2α (single nucleotide polymorphism (SNP) [ch2:46441523(hg18)]) and PHD2 (C/T; SNP rs516651 and T/C; SNP rs480902) are associated with improved adaptation to hypoxia i.e., in...

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PMID: 28613249
DOI: 10.3390/ijms18061266
PMCID: PMC5486088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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