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Article

Hypoxia inducible factor-1 alpha and prolinhydroxlase 2 polymorphisms in patients with severe sepsis: a prospective observational trial.

BMC anesthesiology - 11 Aug 2016

Höcker Annika, Rabeling Miriam, Bick Alexandra, Cox Linda, Kreuzer Maximiliane, Engler Andrea, Walstein Kai, Bachmann Hagen S, Jöckel Karl-Heinz, Eisele Lewin, Adamzik Michael, Peters Jürgen, Schäfer Simon T

Abstract excerpt

BACKGROUND: Hypoxia-inducible-factor-1α (HIF-1α) and HIF-1 degrading prolyl-hydroxylases (PHD) are key regulators of the hypoxic-inflammatory response. Functionally active genetic variants in the HIF-1α (C/T; Single Nucleotide Polymorphism (SNP) rs11549465) and the PHD2 gene (EGLN1; C/T; SNP rs516651 and T/C; SNP rs480902) are associated with altered HIF-1α mRNA nuclear translocation and an altered adaptation to...

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Identifiers

PMID: 27515179
DOI: 10.1186/s12871-016-0225-y
PMCID: PMC4982006

Genes

EGLN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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