Article
Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome.
Intensive care medicine - 1 Aug 2009
Sheu Chau-Chyun, Zhai Rihong, Wang Zhaoxi, Gong Michelle N, Tejera Paula, Chen Feng, Su Li, Thompson B Taylor, Christiani David C
Abstract excerpt
OBJECTIVE: Heme oxygenase-1 (HO-1) acts in cytoprotection against acute lung injury. The polymorphic (GT)n repeat in the HO-1 gene (HMOX1) promoter regulates HMOX1 expression. We investigated the associations of HMOX1 polymorphisms with acute respiratory distress syndrome (ARDS) risk and plasma HO-1 levels. DESIGN: Unmatched, nested case-control study. SETTING: Academic medical center. PATIENTS: Consecutive...
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