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Article

<i>EGLN1</i> variants influence expression and <i>S</i>a<scp>O</scp>2 levels to associate with high-altitude pulmonary oedema and adaptation

8 Nov 2012

Abstract excerpt

EGLN1 [encoding HIF (hypoxia-inducible factor)-prolyl hydroxylase 2] plays a pivotal role in the HIF pathway and has emerged as one of the most intriguing genes with respect to physiology at HA (high altitude). EGLN1, being an actual oxygen sensor, appears to have a potential role in the functional adaptation to the hypobaric hypoxic environment. In the present study, we screened 30 polymorphisms of EGLN1,...

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PMID: 23130672
DOI: 10.1042/cs20120371

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