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Article

Hypoxia Inducible Factor pathway proteins in high-altitude mammals.

Trends in biochemical sciences - 1 Jan 2024

Lee Frank S

Abstract excerpt

Humans and other mammals inhabit hypoxic high-altitude locales. In many of these species, genes under positive selection include ones in the Hypoxia Inducible Factor (HIF) pathway. One is PHD2 (EGLN1), which encodes for a key oxygen sensor. Another is HIF2A (EPAS1), which encodes for a PHD2-regulated transcription factor. Recent studies have provided insights into mechanisms for these high-altitude alleles. These...

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Identifiers

PMID: 38036336
DOI: 10.1016/j.tibs.2023.11.002
PMCID: PMC10841901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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