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The Genomics and Genetics of Oxygen Homeostasis

7 Apr 2020

Abstract excerpt

Human survival is dependent upon the continuous delivery of O2 to each cell in the body in sufficient amounts to meet metabolic requirements, primarily for ATP generation by oxidative phosphorylation. Hypoxia-inducible factors (HIFs) regulate the transcription of thousands of genes to balance O2 supply and demand. The HIFs are negatively regulated by O2-dependent hydrox-ylation and ubiquitination by prolyl...

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PMID: 32255719
DOI: 10.1146/annurev-genom-111119-073356

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