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High-altitude pulmonary edema is aggravated by risk loci and associated transcription factors in HIF-prolyl hydroxylases.

Human molecular genetics - 28 Aug 2021

Sharma Kavita, Mishra Aastha, Singh Himanshu N, Parashar Deepak, Alam Perwez, Thinlas Tashi, Mohammad Ghulam, Kukreti Ritushree, Syed Mansoor Ali, Pasha M A Qadar

Abstract excerpt

High-altitude (HA, >2500 m) hypoxic exposure evokes several physiological processes that may be abetted by differential genetic distribution in sojourners, who are susceptible to various HA disorders, such as high-altitude pulmonary edema (HAPE). The genetic variants in hypoxia-sensing genes influence the transcriptional output; however the functional role has not been investigated in HAPE. This study explored...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34007987
DOI: 10.1093/hmg/ddab139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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