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Article

HIF1A gene polymorphisms and human diseases: Graphical review of 97 association studies.

Genes, chromosomes & cancer - 1 Jun 2017

Gladek I, Ferdin J, Horvat S, Calin G A, Kunej T

Abstract excerpt

Hypoxia-inducible factors (HIFs) belong to a family of transcription factors (TF) responsive to a low O2 availability, which is often a characteristic feature of solid tumors. The alpha subunit of the HIF heterodimer is O2 -sensitive, and once stabilized in hypoxia, it functions as a master regulator of various genes involved in hypoxia pathway. Changes in the HIF1A (hypoxia inducible factor 1, alpha subunit)...

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PMID: 28165644
DOI: 10.1002/gcc.22449
PMCID: PMC5395341

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