Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout Mice

11 Jun 2017

Abstract excerpt

Deficiency of PRG4 (lubricin), the boundary lubricant in mammalian joints, contributes to increased joint friction accompanied by superficial and upper intermediate zone chondrocyte caspase-3 activation, as shown in lubricin-null (Prg4−/−) mice. Caspase-3 activity appears to be reversible upon the restitution of Prg4 either endogenously in vivo, in a gene trap mouse, or as an applied lubricant in vitro. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mitochondrial Function and Pathology
Share to Peroxisome Proliferator-Activated Receptors
Share to Radiopharmaceutical Chemistry and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28604608
DOI: 10.3390/ijms18061252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout MicePMID 28604608Read ↗

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis.Semantic proximity Read ↗

Lubricin Restoration in a Mouse Model of Congenital DeficiencySemantic proximity Read ↗

The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth.Semantic proximity Read ↗

Proteoglycan 4 (Lubricin) and Regulation of Xanthine Oxidase in Synovial Macrophage as A Mechanism of Controlling SynovitisSemantic proximity Read ↗

Prg4 and Osteoarthritis: Functions, Regulatory Factors, and Treatment StrategiesSemantic proximity Read ↗

The biology of Lubricin: Near frictionless joint motionSemantic proximity Read ↗

Disruption of Proteoglycan 4 (PRG4)-CD44 Signaling Modulates Chronic Synovitis in Conditionally Inactivated MiceSemantic proximity Read ↗

Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cellsSemantic proximity Read ↗

Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis ModelSemantic proximity Read ↗

The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration.Semantic proximity Read ↗

Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing.Semantic proximity Read ↗

Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4 versus Aggrecan transgene in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.