Article
Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing.
The Journal of biological chemistry - 2 Sept 2005
Rhee David K, Marcelino Jose, Al-Mayouf Sulaiman, Schelling Deborah K, Bartels Cynthia F, Cui Yajun, Laxer Ronald, Goldbach-Mansky Raphaela, Warman Matthew L
Abstract excerpt
Lubricin, a protein product of the gene PRG4, is a secreted mucin-like proteoglycan that is a major lubricant in articulating joints. Mutations in PRG4 cause the autosomal recessive, human disorder camptodactyly-arthropathy-coxa vara-pericarditis syndrome. We developed rabbit polyclonal antibodies against human lubricin to determine the consequence of disease-causing mutations at the protein level and to study...
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