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Article

Lubricin Restoration in a Mouse Model of Congenital Deficiency

27 Jul 2015

Abstract excerpt

OBJECTIVE: Congenital deficiency of the principal boundary lubricant in cartilage (i.e., lubricin, encoded by the gene PRG4) increases joint friction and causes progressive joint failure. This study was undertaken to determine whether restoring lubricin expression in a mouse model would prevent, delay, or reverse the disease process caused by congenital deficiency. METHODS: Using genetically engineered...

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PMID: 26216721
DOI: 10.1002/art.39276

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