Article
The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth.
The Journal of clinical investigation - 1 Mar 2005
Rhee David K, Marcelino Jose, Baker MacArthur, Gong Yaoqin, Smits Patrick, Lefebvre Véronique, Jay Gregory D, Stewart Matthew, Wang Hongwei, Warman Matthew L, Carpten John D
Abstract excerpt
The long-term integrity of an articulating joint is dependent upon the nourishment of its cartilage component and the protection of the cartilage surface from friction-induced wear. Loss-of-function mutations in lubricin (a secreted glycoprotein encoded by the gene PRG4) cause the human autosomal recessive disorder camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP). A major feature of CACP is...
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