Article

Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis Model

2023-07-04

Abstract excerpt

<h4>ABSTRACT</h4> Osteoarthritis (OA) is a multi-factorial disease associated with aging. As the molecular mechanisms underpinning the pathogenesis of this disease are unclear, there are no disease-modifying drugs to combat OA. Pannexin 3 (PANX3) has been shown to promote cartilage loss during posttraumatic OA. In contrast, the ablation of Panx3 in male mice results in spontaneous full-thickness cartilage lesion...

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Literature Corpus work: 9de48a7d-f563-5f01-bbe7-a76c5f4d8afe
DOI: 10.1101/2023.07.04.547676

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