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Article

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis.

Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2013

Waller Kimberly A, Zhang Ling X, Elsaid Khaled A, Fleming Braden C, Warman Matthew L, Jay Gregory D

Abstract excerpt

Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death, but the connection between these factors is not well established. Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides boundary lubrication in articular joints. Joint friction is elevated and accompanied by accelerated cartilage damage in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23530215
DOI: 10.1073/pnas.1219289110
PMCID: PMC3625316

Genes

PRG4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis.PMID 23530215Read ↗

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Cartilage Derived from Bone Marrow Mesenchymal Stem Cells Expresses Lubricin In Vitro and In VivoSemantic proximity Read ↗

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