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Article

The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration.

International journal of molecular sciences - 22 Jan 2021

Serjeant Meaghan, Moon Paxton M, Quinonez Diana, Penuela Silvia, Beier Frank, Séguin Cheryle A

Abstract excerpt

Pannexin 3 (Panx3) is a mechanosensitive, channel-forming glycoprotein implicated in the progression of post-traumatic osteoarthritis. Despite evidence for Panx3 expression in the intervertebral disc (IVD), its function in this cartilaginous joint structure remained unknown. Using Panx3 knockout mice, this study investigated the role of Panx3 in age-associated IVD degeneration and degeneration induced by annulus...

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Source

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Identifiers

PMID: 33499145
DOI: 10.3390/ijms22031080
PMCID: PMC7865929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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