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Article

The CaMKII holoenzyme structure in activation-competent conformations.

Nature communications - 7 Jun 2017

Myers Janette B, Zaegel Vincent, Coultrap Steven J, Miller Adam P, Bayer K Ulrich, Reichow Steve L

Abstract excerpt

The Ca2+/calmodulin-dependent protein kinase II (CaMKII) assembles into large 12-meric holoenzymes, which is thought to enable regulatory processes required for synaptic plasticity underlying learning, memory and cognition. Here we used single particle electron microscopy (EM) to determine a pseudoatomic model of the CaMKIIα holoenzyme in an extended and activation-competent conformation. The holoenzyme is...

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Identifiers

PMID: 28589927
DOI: 10.1038/ncomms15742
PMCID: PMC5467236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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