Article

Conformational Spread Drives the Evolution of the Calcium-calmodulin Protein Kinase II

2021-05-12

Abstract excerpt

The calcium calmodulin (Ca 2+ CAM) dependent protein kinase II (CaMKII) decodes Ca 2+ frequency oscillations. It has a central role in learning. I matched residue and organismal evolution to collective motions deduced from the atomic structure of the human CaMKIIa holoenzyme. Protein dynamic simulations and bioinformatic analysis showed its stacked ring architecture conformationally couples kinase domains (KDs) vi...

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Literature Corpus work: 1d2ed98d-f933-5054-913a-73a7f22019d1
DOI: 10.21203/rs.3.rs-506808/v1

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