Article

Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation

2019-08-01

Abstract excerpt

Ca 2+ -calmodulin dependent protein kinase II (CaMKII) plays a central role in Ca 2+ signaling throughout the body. Specifically in the hippocampus, CaMKII is required for learning and memory. CaMKII is encoded by four highly conserved genes in vertebrates: α, β, γ, and δ. AllCaMKIIs are comprised of a kinase domain, regulatory segment, variable linker region, and hub domain responsible for oligomerization. The...

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Literature Corpus work: 57b24933-2a40-580c-8ba9-ea05838ff4f2
DOI: 10.1101/721589

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