Article
Structural insights into the architecture and allostery of full-length AMP-activated protein kinase.
Structure (London, England : 1993) - 13 Apr 2011
Zhu Li, Chen Lei, Zhou Xiao-Ming, Zhang Yuan-Yuan, Zhang Yi-Jiong, Zhao Jing, Ji Shang-Rong, Wu Jia-Wei, Wu Yi
Abstract excerpt
AMP-activated protein kinase (AMPK) is a heterotrimeric complex composed of α catalytic subunit, β scaffolding subunit, and γ regulatory subunit with critical roles in maintaining cellular energy homeostasis. However, the molecular architecture of the intact complex and the allostery associated with the adenosine binding-induced regulation of kinase activity remain unclear. Here, we determine the...
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