Article

Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+/Calmodulin-dependent protein kinase II

2019-01-31

Abstract excerpt

The multi-subunit Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) holoenzyme plays a critical role in animal learning and memory. The kinase domain of CaMKII is connected by a flexible linker to a C-terminal hub domain that assembles into a 12- or 14-subunit scaffold that displays the kinase domains around it. Studies on CaMKII suggest that the stoichiometry and dynamic assembly/disassembly of hub oligomer...

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Identifiers and source

Literature Corpus work: 854fa194-cb34-514d-b535-b88da8a0e1f7
DOI: 10.1101/536094

Open publication

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