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Article

CaMKIIα holoenzymes self-organize into chain-like mesoscale clusters.

Science advances - 11 Sept 2026

Suzuki Taisei, Sumikama Takashi, Matsushima Keisuke, Hasegawa Kodai, Sumino Ayumi, Umeda Kenichi, Kodera Noriyuki, Das Tamoghna, Beta Carsten, Murakoshi Hideji, Shibata Mikihiro

Abstract excerpt

Calcium- and calmodulin-dependent protein kinase II (CaMKII) is highly enriched in dendritic spines at concentrations comparable to those of cytoskeletal proteins and plays a central role in synaptic plasticity. During long-term potentiation, CaMKIIα further accumulates in spines. However, the mechanisms governing its higher-order organization remain poorly understood. Here, we use high-speed atomic force...

Read the complete abstract on PubMed

Topics

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Animals
Holoenzymes
Microscopy, Atomic Force
Dendritic Spines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Protein Binding

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42726843
DOI: 10.1126/sciadv.aeg0958
PMCID: PMC13564840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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